The Colonels had big first-half leads earlier this month on the road against Northern Kentucky and Marshall.
They weren't able to win either of those games.
A very similar scenario played out on Saturday in Greenville, N.C.
EKU (3-10) raced out to a 10-point advantage against East Carolina and took a seven-point lead (39-32) into halftime. The Pirates used two big runs in the second half to rally and claim a 82-74 win over the Colonels.
The loss was the eighth-straight for EKU - the program's longest losing streak in 19 years.
Jomaru Brown had 25 points and six rebounds as the Colonels fell to 0-6 on the road this season.
EKU shot just 28.6 percent from the field in the second half.
Jayden Gardner had 25 points and 14 rebounds as the Pirates (6-7) won their four-straight game for the first time since 2013.
"I'm proud of my guys, I hate losing, but we played much better," EKU coach AW Hamilton said in a postgame radio interview. "Now, we've got to get geared up for OVC play. These kids are fighting. They are fighting their tales off."
The game marked the end of the non-conference schedule for the Colonels.
EKU opens Ohio Valley Conference play on Thursday at home against Tennessee Tech.
The Colonels came into the game second among all NCAA Division I teams in turnovers forced a game (21.2). The Pirates had 22 on Saturday, which led to 22 points, but EKU had 18 turnovers, which lead to 20 points.
"You've got to take care of the ball," Hamilton said. "That's always the No. 1 thing. We didn't do that."
The Colonels ran out to a 12-3 lead behind the strong play of Ty Taylor. A three-point play by Tre King put EKU up 20-10.
ECU got within three points late in the first half, but King had a tip-in, a basket and hit his first three of the game.
EKU had a 47-40 advantage before the Pirates used an 11-0 run to take their first lead since 2-0.
The Colonels trailed 60-51 but bounced back.
Michael Moreno hit a pair of three-pointers, then Rushard Cruickshank and Taylor connected from long range.
"Three or four weeks ago, we probably would have folded when they hit us with that run. We responded," Hamilton said.
The Colonels got within two points, 65-63, before ECU used a 9-0 run to regain control.
EKU got back within three points with 1:44 left. The Pirates scored seven of the final nine points of the game, though, to seal the win.
King had 18 points and 12 rebounds. Taylor had 12 points. Moreno had 11 points. Darius Hicks had five points.
The Colonels were 8-of-27 three-point range and shot 35.6 percent overall from the field.
EKU was out-rebounded 44-39.