The Colonels missed 16 of their first 17 field goal attempts on Tuesday against USC-Upstate.
And that poor shooting performance was just too much to overcome.
EKU battled back, but suffered a 79-67 loss to the Spartans in Spartanburg, S.C.
The Colonels missed their first eight three-point attempts and trailed 30-17 at the half.
EKU's record falls to 3-5 on the season with a third-straight loss.
USC-Upstate took a 25-point lead, 44-19, when Josh Aldrich converted a pair of foul shots with 15:33 remaining in the game. However, EKU outscored the Spartans 26-9 over the next seven minutes.
A four-point play by senior Ty Taylor capped an 11-0 EKU run and cut the deficit to eight, 53-45, with 8:24 left.
USC-Upstate regrouped and rattled off the next seven points. A fast-break bucket by Everette Hammond pushed the Spartans' lead back to 15, 60-45, with 6:40 on the clock.
The Colonels kept battling, as a steal and bucket by junior Jacquess Hobbs made it a single-digit game again, 76-67, with 28 seconds remaining. USC Upstate converted three free throws down the stretch to hold on for the 79-67 win.
Sophomore Jomaru Brown led EKU with 17 points. Taylor finished with 14 points. Sophomore Tre King just missed a double-double, recording 13 points and nine rebounds.
Hammond led all players in the game with 27 points.
The Colonels return to action on Sunday when they go on the road to face Northern Kentucky. Tip from Highland Heights is scheduled for 7 p.m.