Chip McDaniel had only one bogey through the first two days of the Unbridled Tour event at Boone's Trace National Golf Club.
He carried a two-shot lead into Thursday's final round.
The former University of Kentucky needed a strong finish, though, to hold on for the title.
McDaniel shot his highest round of the tournament, a 67, but had four birdies on the back nine to claim a $10,000 prize.
He shot a -19, 197 for the tournament.
Dylan Meyer took the lead late in the final round, but finished second with a three-round total of -17, 199. He shot the lowest score of the day (-7, 65).
McDaniel had a birdie on No. Thursday to move to -15 for the tournament. The Manchester had a bogey on No. 6 and made the turn at -1 for the day.
He got back on track after that.
McDaniel had birdies on No. 10, 11 and 13. He sealed the title when he holed out a shot from just short of the bunker on No. 18.
McDaniel birdied the final hole in all three rounds.
Meyer shot a 64 on Tuesday, before posting a 70 on Wednesday.
He birdied four of the first six holes in the final round and made the turn at five-under.
Meyer, who played at the University of Illinois, also had birdies on No. 10 and No. 13 as he jumped to the top of the leaderboard.
Jacob Poore, who played at Northern Kentucky University, entered the final round in second place. He shot a -3 69 on Thursday and finished in third place with a total score of -15, 201.
Erik Barnes (202) was fourth, while Kent Bulle, Jacob Cook and Cooper Musselman (204) all tied for fifth.
McDaniel played 133 collegiate rounds for Kentucky with a 72.00 stroke average. His senior season was highlighted by a victory at the Bearcat Invitational where he fired a career-low 54-hole total of 201. That marked the second-lowest score in the Brian Craig era.
The Unbridled Tour event was the first professional golf tournament in Kentucky since the COVID-19 outbreak.