The Lady Indians found themselves facing a big deficit in the opening minutes when they took on preseason 11th Region favorite Franklin County earlier this month in Richmond.
The same scenario played out again on Monday in Frankfort.
The Lady Flyers (15-5) scored the first eight points of the game and used that momentum to roll to a 64-28 win over Madison Central (11-15) in the opening round of the 11th Region Tournament.
The Lady Indians had 26 turnovers and shot just 21.7 percent from the field in the season-ending loss.
Bailey Hensley had eight points and eight rebounds to lead Central.
"Turnovers got us down early," Madison Central coach Brad Lovely said. "When we got them in a half-court game, we played well. We fought hard, but just couldn't score against their size."
The Lady Flyers will take on Tates Creek on Wednesday in the semifinals at McBrayer Arena.
In the only regular-season meeting between the teams, Franklin County jumped out to a 12-0 lead on the way to a 59-33 win.
The Lady Flyers scored 11 points off turnovers in the first quarter on Monday and carried a 15-6 lead into the second. At halftime, the advantage had grown to 16 points (29-13).
Patience Laster had 21 points and 13 rebounds for Franklin County. Brooklynn Miles had 14 points and seven assists, while Nevah Carter had 11 points, eight rebounds and seven assists.
Franklin County out-rebounded Central, 44-34.
Eve Carter had five points and four rebounds for Central. Gretchen Hammitt had four points. Brianna Bierbaum and Presley Lochmueller had three points each. Nataya Strader had two points and Brooke Campbell had one point. Brittany Campbell finished with four rebounds.
The Lady Indians were 1-of-6 from three-point range and 7-of-14 from the free throw line.